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In rodents, intracerebroventricular (ICV) administration of the GLP-1R antagonist exendin-9 suppressed the effects of peripheral GLP-1R agonist administration (liraglutide and exenatide) on food intake reduction

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Some patients experience transient anxiety during dose increases, while others feel calmer as weight drops and physical wellness improves

The prior authorization process requires documentation of comorbid medical conditions that can be improved or eliminated by taking GLP-1 medications

Societal pressures and weight-shaming can cause low self-esteem, negative body image, and poor quality of life